Selectivity and Detectability Optimizations in HPLC

Here is the first full treatment of selectivity and detectability optimizations in chromatography. After describing the scope of selectivity and detectability optimizations, chapters explain the physicochemical basis of retention and survey illuminating studies on separation mechanisms. The book presents conventional approaches used to optimize mobile-phase selection and optimization and describes optimization of separations in adsorption/normal-phase, reversed-phase, ion-exchange, and ion-pairing chromatography. Closing chapters discuss applications pertaining to macromolecules and isomers, computerized approaches to selectivity, and selective detectors.