Differential Mobility Spectrometry: FAIMS and Beyond

Alexandre A. Shvartsburg
11/14/2008
Explores the theoretical and practical aspects of FAIMS and other examples of the nonlinear IMS paradigm derived from the latest ongoing researchIntroduces original, unpublished research results and extensive FAIMS work not otherwise available in EnglishFocuses on integrating FAIMS into the toolbox of analytical, physical, and structural chemistryCompares the major analytical features of FAIMS with traditional MS, IMS, and liquid-phase separationsContains figures, equations, tables, graphs, 1D and 2D spectra, photographs, and hardware schemes/diagrams on nearly every page

A premier tool of analytical chemistry, mass spectrometry (MS) separates ionized molecules by the mass/charge ratio. Field Asymmetric waveform. Ion Mobility Spectrometry (FAIMS) is a new analytical method that enables novel miniaturized devices and greatly enhances the capabilities of mass spectrometry, revolutionizing its applications. The first book devoted to this rapidly growing field, this text introduces the new paradigm of nonlinear ion mobility spectrometry, using FAIMS as its principal example. It integrates fundamentals of high-field and differential ion mobility, instrumental aspects of FAIMS, and applications including drug discovery, proteomics, trace detection in security and defense settings, forensics, and environmental analysis.