High-Throughput Analysis in the Pharmaceutical Industry

Perry G. Wang
7/25/2008
Covers drug discovery including pharmacokinetics and metabolism Features contributions from well-known, active scientists Describes high-throughput analysis for the pharmaceutical industry Presents advanced instrumentation and automation methods for drug analysis

High throughput analysis plays a critical role in the pharmaceutical industry. The ever-shortening timelines and high costs of drug discovery and development have brought about the need for high throughput approaches to methods that are currently used in the industry. Written and edited by well-known contributors who remain active in this line of research, this book systematically describes high throughput analysis for the pharmaceutical industry, including advanced instrumentation and automated sample preparation. The text discusses various techniques, including HPLC, MALDI-MS, and LC-MS/MS methods, with an emphasis on the later stage of drug development, including pharmacokinetics.

Table of Contents
Strategies for High Throughput Analyses of Drugs and Metabolites in Biological Matrix. High Throughput Tools and Automation for Drug Discovery. Online Sample Extraction Coupled with Multiplexing Strategy to Improve Throughput. Development of Rapid HPLC Methods for Increasing Sample Throughput. Online Solid Phase Extraction and Liquid Chromatography/Mass Spectroscopy for High Throughput Bioanalysis. Mass Spectroscopy Analysis in High Throughput Screening and Compound Library Management. High Throughput Analysis in Early Drug Discovery. High Throughput Sample Preparation Techniques and their Application to Pharmaceutical Analysis and Combinatorial Synthetic Libraries Purification. High Throughput Analysis for Pre-Clinical and Clinical Studies. Liquid Chromatographic Separation for High Throughput Analysis by LC-MS and HPLC (UV). High Throughput Metabolite Identification in Support of Drug Discovery. High Throughput Quantitative Analysis of Peptides and Proteins by Mass Spectroscopy. High Throughput Pharmaceutical Analysis in DMPK. High Throughput Strategies and Techniques for Method Development. Application of High Throughput Analysis in Protein Drugs. High Throughput Qualitative Analysis in Drug Discovery using LC-MS/MS.