A. Ramamoorthy
9/22/2005
Includes a comprehensive selection of chapters
from both academic
and industrial perspectives, authored by world renowned experts Illustrates how results elucidate chemical bonding,
molecular shape and geometry, local and global molecular dynamics, folding, and intermolecular interactions Describes how to extrapolate
the three-dimensional organization of molecules in microcrystalline states Highlights solid-state NMR抯 applicability to non-soluble, non-crystalline biological, material, and chemical molecules, including polymers, glass, silk, amyloids, lipids, and collagen Shows how the study of aligned systems and three-dimensional
structure of membrane proteins can explain a variety of biological mechanisms of action
Over the past decade, a myriad of techniques have shown that solid-state nuclear magnetic resonance (NMR) can be used in a broad spectrum of
applications with exceptionally impressive results. Solid-state NMR results can yield high-resolution details on the structure and function of many important biological solids, including viruses, fibril-forming molecules, and molecules embedded in the cell membrane.
Filling a void in the current literature,NMR Spectroscopy of Biological Solidsexamines all the recent developments, implementation, and interpretation of solid-state NMR experiments and the advantages of applying them to biological systems. The book emphasizes how these techniques can be used to realize the structure of non-crystalline systems of any size. It explains how these isotropic and anisotropic couplings interactions are used to determine atomic-level structures of biological molecules in a non-soluble state and extrapolate the three-dimensional structure of membrane proteins using magic-angle spinning (MAS). The book also focuses on the use of multidimensional solid-state NMR methods in the study of aligned systems to provide basic information about the mechanisms of action of a variety of biologically active molecules.
Addressing principles, methods, and applications, this book provides a critical selection of solid-state NMR methods for solving a wide range of practical problems that arise in both academic and industrial research of biomolecules in the solid state.NMR Spectroscopy of Biological Solidsis a forward-thinking resource for students and researchers in analytical chemistry, bioengineering, material sciences, and structural genomics.
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