John Roboz 3/25/2002 Search this book Provides an overview on how mass spectrometers work and what type of information they provideIntroduces applicationswith succinct summaries of biological, pharmacological, or medical background with references to recent reviews Covers literature through July 2001Includes approximately 1800 references, many selected for informational or educational valueOffers approximately 240 figures and 30 tables
Cancer research is becoming multidisciplinary. The complex structural and therapeutic problems require synergistic approaches employing an assortment of biochemical manipulations, chromatographic or electrophoretic separations, sequencing strategies, and ?more and more mass spectrometry.
Mass Spectrometry in Cancer Research provides a broad examination of current strategies and techniques and their application to the study of: (i) occupational and environmental carcinogens; (ii) antineoplastic and chemopreventive agents; (iii) pertinent proteins, lipids, nucleic acids and glycoconjugates. Also included are a chapter on instrumentation and methodologies for biologists and physicians and a brief review of the relevant concepts of cancer biology and medicine for mass spectrometrists.
This book is intended for: mass spectrometrists in research or those providing core services; researchers in biological, medical, pharmaceutical or environmental sciences; physicians in academic medicine; and academic/industrial research managers.
Search this book Table of Contents OVERVIEW AND SCOPE OF APPLICATIONS The Essentials Functions and Types of Instrument Components Measures of Performance Information from Mass Spectra and Scope of Applications INSTRUMENTATION AND TECHNIQUES OF MASS SPECTROMETRY Ion Sources Mass Analyzers Ion Current Detectors Mass Spectrometry-Mass Spectrometry (MS/MS) Identification and Quantification Resources RELEVANT CONCEPTS OF CANCER MEDICINE AND BIOLOGY Classification and Epidemiology Cellular Proliferation and Communication Genetic Abnormalities in Cancer Tumor Immunology Diagnosis and Treatment Some Pertinent Experimental Methods METABOLISM AND BIOMARKERS OF CARCINOGENS Classification, Mechanisms of Action and Biomarkers Occupational Carcinogens Environmental Carcinogens DNA Damage by Radiation and Oxidation ANTINEOPLASTIC AND CHEMOPREVENTIVE AGENTS Cytotoxic Therapy Endocrine Therapy Targeted Drug Delivery and Therapy Nutritional and Chemical Prevention STRATEGIES, TECHNIQUES AND APPLICATIONS IN CANCER BIOCHEMISTRY AND BIOLOGY Proteins and Peptides Lipids Oligonucleotides and Nucleic Acids Carbohydrates and Glycoconjugates REFERENCES INDEX
