A tribute to the pioneering scientific work of Professor Koji Nakanishi, whose studies of natural products have effaced some of the conventional boundaries between biologyandchemistry. It discusses an array of chromatographic separation methods and determination of structures on a microscale, analyzes bioassay-directed fractionation and other means of isolating biologically active compounds from plants and other sources, covers vital enzymes isolated from marine organisms such as algae, and more.
Search this book Table of Contents Insect antifeeding limonoids from the chinaberry tree melia azedarach linn and related compounds; polygodial and warburganal, antifungal sesquiterpene dialdehydes and their synergies; marine bromoperoxidases-chemoenzymatic applications; LC-hyphenated techniques in the search for new bioactive plant constituents; determination of the absolute configuration of biologically active compounds by the modified Mosher's method; circular dichroism spectroscopy and the absolute stereochemistry of biologically active compounds; recent applications of circular dichronism to carbohydrate conformational analysis and direct determination of drug levels; furan-terminated cationic pi-cyclization in the synthesis of natural products; chemistry and biology of semisynthetic avermectins; chemical and biological approaches to molecular diversity - applications to drug discovery; imidazoline receptors and their endogenous ligands; oxidoredox suppression of fungal infections by novel pharmacophores; a mechanistic analysis of C-O bond cleavage events with a comparison to 3,6-dideoxysugar formation; the molecular mechanism of amyloidosis in Alzheimer's disease; bacteriorhodospin structure/function studies -use of the dimethyl retinal analogs for probing of the Arg82Ala mutant; autonomous genomes; stereo-chemical considerations of immunoglobulin heavy chain enhancer activation.
