Gene Expression at the Beginning ofAnimal Development (Advances in Developmental Biology and Biochemistry,Volume 12) (Advances in Developmental Biology and Biochemistry, V. 12)
By
M.L. DePamphilis
- Publisher: Elsevier Science
- Number Of Pages: 296
- Publication Date: 2002-09-01
- ISBN-10 / ASIN: 0444510486
- ISBN-13 / EAN: 9780444510488
- Binding: Hardcover
Book Description:
Thebeginning of life may be a miracle to some, and a mystery to others,but it is certainly one of the most exciting and perhaps controversialfields of scientific investigation in the 21st century. Among themetazoa, life begins when an egg is fertilized by a sperm. The spermprovides a genetic blueprint from the father and perhaps some criticalproteins. The egg provides a genetic blueprint from the mother togetherwith a large reservoir of mRNAs and proteins that are required for DNAreplication, cell division and the onset of zygotic gene expression.All of the thousands of genes in these two mature gametes aretranscriptionally silent and remain so until fertilization.
Thiswork focuses on three biological systems, providing the reader with aclear understanding of the current state of affairs, and the ability toidentify common principles as well as critical differences that areresponsible for beginning the process of animal development.
Theessays presented will be of practical value to all those who areinterested in improving fertilization in vitro, in designing novelmethods of contraception, in developing preimplantation geneticdiagnosis for various diseases, in cloning animals by transplantingnuclei from adult cells to an enucleated egg, and in the application ofembryonic stem cells to curing genetic diseases or replacing damagedtissues. But above all, this volume is offered to those who simply havean insatiable curiosity about life and its beginnings.
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